Archive for the ‘Uncategorized’ Category

Blog survey

March 15th, 2008 1 Comment

I am gathering information about who my readers are in order to be better able to serve them. I started this blog for a grad school class and I would like your input on what you think of my blog. With that said, I’d appreciate it if you could fill out my 10-question survey. I welcome all suggestions.

Thank you!

Click Here to take my quick blog survey

Please welcome the newcomers: SARS and avian flu. But, don’t forget about the oldies: anthrax, smallpox and plague.

While some defense experts fear these new and old infectious diseases may look attractive to bioterrorists, one expert thinks synthetic biology may the biggest threat to security, according to an opinion piece by Wendy Orent in the Los Angeles Times.

But, what’s synthetic biology even mean?

According to SyntheticBiology.org:

Synthetic biology refers to both:

  • the design and fabrication of biological components and systems that do not already exist in the natural world
  • the re-design and fabrication of existing biological systems.

The fear is that scientists or bioterrorist organizations could make their own diseases in the laboratory to be used for terrorism, according the LA Times.

The article also discusses a group of scientists who successfully synthesize a bacterial genome from scratch. Regardless of the feat, the group of scientists was unable to put the bacteria in a living cell to show that it could grow and multiply. This means the U.S. government doesn’t have to worry about spending countless dollars to combat these synthetic threats. Not just yet, at least.

After 9/11, the U.S. government poured billions into Project BioShield, which aimed to provide countermeasures to protect Americans from biological and chemical threats. Today, the program has little to show for itself, with the government moving toward a broader target of threats instead of focusing on individual diseases.

It looks like the U.S. biodefense program is creeping in a new direction, according to the LA Times opinion piece:

Indeed, the fear of dangerous synthetic germs has prompted the enormous, cumbersome apparatus that is the U.S. biodefense program to lurch in a new direction. If we don’t know what pathogens are coming, the reasoning goes, we had better develop new ways of countering them — not one at a time but all of them.

Scientists get access to all sorts of crazy organisms and chemicals. We trust them with these sometimes deadly substances. What happens when a scientist with a promising career steals bacteria and tries to do the unthinkable with it?

A biomedical researcher from the United Kingdom took potentially-deadly germs from a hospital lab in a plan in a plan to end her life, according to Britain’s Daily Mail.

Jennifer Bainbridge acted in despair after suffering from depression for months. But, she stopped herself before administering a bacterium she had removed from the hospital.

Bainbridge told the Daily Mail:

“I was basically going to give myself septicemia. I just took what was available in the lab, but I made sure they were organisms which were not going to put anyone else at risk.

“I didn’t go through with it in the end because it was silly and a few days later I told staff.

“Even thinking about it all now makes me upset.”

Septicemia is a bacterium found in MRSA – a strain of staph resistant to the antibiotic methicillin – and E. coli germs.

MedicineNet.com gives the following definition:

Septicemia: Systemic (body wide) illness with toxicity due to invasion of the bloodstream by virulent bacteria coming from a local seat of infection. The symptoms of chills, fever and exhaustion are caused by the bacteria and substances they produce. The disorder is treated with massive doses of antibiotics. Also known as blood poisoning.

Bainbridge confessed everything to her boss and was taken off the health professions council register for 18 months, according to the Daily Mail.

About.com’s Infectious Disease blogger Anna Spector weighed in on the issue:

“Lab life leaves people very isolated and it wouldn’t surprise me to hear she isn’t the only one who has taken germs home, on purpose that is.”

Well said. I wonder if Spector is right about this. If so, I hope there are caring coworkers out there who notice when something is wrong and do their part to help.

I had the privilege of chatting with Dr. Michael Barza on Friday about what’s going on in the field of infectious diseases. Barza is the Chief of Medicine and Program Director for Internal Medicine at Caritas Carney Hospital and also Vice Chairman for Operations and Associate Chief of Medicine at New England Medical Center, both of which are in Boston, Mass. Barza also serves as the Deputy Editor of the journal Clinical Infectious Diseases.  

Click below to hear the interview.

Interview with Dr. Michael Barza

 

Here’s the transcript:

Christina Zdanowicz: How long have you been working in the field of infectious disease and what specifically is your specialty?

Dr. Michael Barza: For 40 years. At least I began my fellowship in 1968 at New England Medical Center. And my specialty is probably antibiotics, pneumonia, fevers of unknown origin. Those would be my main areas of interest.

CZ: What’s you affiliation with the Clinical Infectious Diseases journal?

MB: I’m the deputy editor of that journal. My main duty is to take the first look at virtually all of the unsolicited manuscripts, which is most of the manuscripts – about 2,500 a year. I take the first look at those and decide if I think we should be interested in sending them out for review or declining them without review.

CZ: What is the exact scope or what are some of the topics in that journal?

MB: It’s very broad reaching. It covers all aspects of infectious disease ranging from hospital epidemiology to immunization practices to infections by virtually any kind of pathogen: viruses, bacteria, fungi, parasites. As well as sometimes dealing with issues of ethics, of efficiency of consultations of sort of general topics like that. So, virtually all aspects of infectious disease but the emphasis is upon clinical infectious diseases, not so much in basic research, or if its basic research, it must be something applicable more or less now.

CZ: What are some of the hot topics relating to infectious diseases that the journal has been publishing about more recently? 

MB: In terms of viruses, influenza, both influenza A and B that we have in this country already as well as H5N1. Influenza has been a big topic. Other viral infections, of course HIV is always an important topic. Lately, we’ve actually had quite a few studies of treatment issues in HIV in developing countries – Africa, southeast Asia and so on.

In terms of bacterial infections, the biggest issue is probably been MRSA, which is an acronym for Methicillin-resistant Staphylococcus aureus. We’ve also had quite a bit on resistant bacteria, especially resistant Gram-negative bacteria, especially in intensive care units and elsewhere in hospitals, multi-resistant organisms, which have been an increasing problem in mot countries. Sticking with bacteria, tuberculosis continues to be a major killer and in particular now, there’s been a great deal of concern about multi-drug resistant tuberculosis. So called XDR, extended drug resistant TB. These organisms are actually resistant to virtually every antimicrobial that we can throw at them.

Then, a number of parasitic infections, malaria continues to be a major killer and cause of morbidity in a lot of countries, so we continue to have an interest in trials of new anti-malarial agents. 

CZ: And anything coming up in the new issue of the journal that is really groundbreaking or something that the community will really latch onto?

MB: Well, I haven’t looked yet at what’s on. I see these things usually several weeks in advance and I can’t remember what’s on for the next issue. I don’t remember anything that’s earth shattering. There is, in a few weeks, we’re going to have expedited publication, which we hardly ever do, of an article describing a kind of outbreak of a kind of E. coli in the United Kingdom. A kind of E. coli infection that can sometimes cause serious damage to the kidneys, it’s called the hemolytic uremic syndrome. In fact that manuscript is going to be the basis of an inquiry by some judicial commission in the United Kingdom. So we have been considering releasing that in expedited form.           

CZ: That sounds like something really explosive potentially if it’s going to a judicial committee. 

MB: It does have public health implications in part because mostly because there’s some evidence that these infections could be transmitted from child to child, I guess from adult to child too, or vice versa, but there have been some cases of transmission, so they want to alert the public that if one child has some of these symptoms, they should be kept separate from other children. So, I think that, in part, will be the subject of the inquiry. 

In just the month of January, infectious diseases claimed the lives of 571 people in China, according to Mathaba News Agency. The number of reported infectious disease cases in January was 370,000.

The top five infectious diseases responsible for the deaths were: tuberculosis, rabies, AIDS, hepatitis B, and measles, according to the article.

The article did not compare January’s infectious disease fatalities to figures from previous months.

Back in 2006, the Chinese government and the World Health Organization established a center in the Guangdong Province to fight emerging infectious diseases. The center’s focus has been on disease surveillance and prevention. The mission of this center and those in other provinces has been to provide a training base for neighboring countries.

According to the WHO press release:

“The WHO collaborating centre in Guangdong is a milestone in China’s contribution to global public health,” said Vice-Minister Huang. “It reflects our country’s commitment to playing a prominent role in this regard, at an especially critical moment in public health history.”

Genetic-mapping by computers may now enable doctors to pin down infectious diseases that fool today’s medical tests, according to a new study.

The infectious disease community hopes this new tool for identifying diseases that slip by undetected will facilitate quicker responses to disease outbreaks.

An expert told USAToday:

“There is no doubt that this technology is going to play a major role in our defenses,” said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases. The coordinated global response showed “the way it should work” when a new killer bug emerges.

He and other experts are particularly concerned about the threat of a pandemic as cases of bird flu mount around the world.

“This is new technology that has spectacular power,” he says. “It’s extraordinary in its capability and it was manifested in a very dramatic case.”

A team of researchers examined a mysterious cluster of deaths in Australia in April, using standard tools to identify what bacteria or virus may have befell the group of middle-aged women who had received organs from the same donor, the paper said. After weeks of work, the researchers came up empty-handed, as the virus didn’t show up on any tests.

Researchers used the computerized sequencing tools that mapped out the human genome, but used RNA, ribonucleic acid, instead of DNA – the material that carries our genetic information.

The mapping revealed 14 sequences that appeared to be the mark of a new arenavirus, which most commonly is transmitted to humans via rodent urine, according to the study.

Ian Lipkin, one of the authors, told USAToday that the new genetic-mapping tool can be used to respond more quickly to everyday infectious diseases, like pneumonia and diarrhea, as well as the threat of a pandemic.

“Speed and accuracy of pathogen identification are increasingly important,” Lipkin says, because every day that passes as scientists try to find a killer bug means another day in which an outbreak can spread among global travelers.

The study was published online Wednesday in the New England Journal of Medicine. Click here to read the paper.

grapefruit

A grapefruit a day keeps Hepatitis C away? That may be the case, according to a team of scientists from the Massachusetts General Hospital Center for Engineering in Medicine.

A naturally occurring compound found in grapefruit and other citrus may be able to block the secretion of hepatitis C virus from infected cells, according to Medicine World’s Infectious Disease blog. A flavonoid called naringenin is responsible, and researchers believe it may help in potentially removing the virus from a hepatitis C patient.

According to the National Cancer Institute, a flavonoid is:

A member of a group of substances found in many plants and plant-based foods. Flavonoids have shown antioxidant effects.

In order to pass the infection on to other liver cells, the virus must attach itself to a very low-density lipoprotein, or vLDL, also known as bad cholesterol.

The lead author of the study, published online Monday in the journal Hepatology, discussed the impacts of the discovery with Foodconsumer.org:

“These results suggest that lipid-lowering drugs, as well as supplements, such as naringenin, may be combined with traditional antiviral therapies to reduce or even eliminate HCV from infected patients,” said Yaakov Nahmias, PhD, of the MGH-CEM, the paper’s lead author.

What do you think?

February 3rd, 2008 1 Comment

Hey everyone, for some reason the ‘What do you think’ page I created doesn’t provide a place for reader comments. For the time being, please post your comments here. Feel free to tell me what you think. Thank you!

What would happen if cases of infectious diseases were going unreported? Unfortunately, a study released in Ireland has revealed that doctors are underreporting the incidence of infectious diseases by about 20 percent.

Ireland’s Health Service Executive, which provides health and social services to the country, found that hospitalization figures did not match the number of actual cases of illness caused by infectious diseases. The research was conducted over a six-year period.

Hospital staff failed to record 18 percent of infectious disease cases, which translates to over 570 missed cases due to underreporting. Viral hepatitis C, viral meningitis, infectious mononucleosis and acute encephalitis made up the majority of underreported cases, according to the study.

According to The Sunday Business Post:

The unit blamed what one of the leading experts described as ‘‘a culture of non-compliance’’ among doctors and other clinicians with the procedures to notify the HSE. Dr Peter Finnegan, specialist in public health medicine with the HSE Dublin North, said there was ‘‘a big gap’’ in the reporting of cases by GPs.

‘‘There seems to be an attitude that, if one is a busy doctor, the time given to complying with the notification process would be bothersome,” he told The Sunday Business Post.

It’s scary to think about what may happen if too many cases of infectious disease go unreported. Quickly identifying cases allows for timely action by public health officials and makes it easier to monitor the disease. Keeping tabs on infectious diseases is essential to preventing outbreaks — or an epidemic.

healthmap23.jpg

The other day I stumbled upon a world map that tracks outbreaks of infectious diseases. HealthMap gives a nearly real-time depiction of diseases striking all parts of the world. Balloons dot the map, indicating the “heat index” of a particular area. Red is the hottest reading. The recency of alerts, number of outbreaks and number of sources reporting at that location are all taken into account.

As of this evening, the West Bengal region of India appeared to have the most serious outbreak status. By rolling over the red balloon, I saw that avian influenza, influenza, Polio and undiagnosed diseases were prominent in this area.

The data is gathered from a variety of sources, some of which are more reliable than others. Information comes from news sources, curated personal accounts and official data.

Google Maps Mania provided some interesting insight into what HealthMap could mean for the world:

“When you really stop to think about what power this mashup has it really serves to help millions of people to stay up to date on what health-related sources are currently reporting all over the world.”